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Miao A, Luo T, Hsieh B, Edge CJ, Gridley M, Wong RTC, Constandinou TG, Wisden W, Franks NP. Brain clearance is reduced during sleep and anesthesia. Nat Neurosci. 2024 May 13. doi: 10.1038/s41593-024-01638-y. Epub ahead of print. PMID: 38741022.

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Tossell K, Yu X, Giannos P, Anuncibay Soto B, Nollet M, Yustos R, Miracca G, Vicente M, Miao A, Hsieh B, Ma Y, Vyssotski AL, Constandinou T, Franks NP, Wisden W. Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus. Nat Neurosci. 2023 Oct;26(10):1805-1819. doi: 10.1038/s41593-023-01430-4. Epub 2023 Sep 21. PMID: 37735497; PMCID: PMC10545541.

 

Nollet M, Franks NP, Wisden W. Understanding Sleep Regulation in Normal and Pathological Conditions, and Why It Matters. J Huntingtons Dis. 2023;12(2):105-119. doi: 10.3233/JHD-230564. PMID: 37302038; PMCID: PMC10473105.

 

Wisden W, Franks NP. Biochemical pathways of sleep. Cell Res. 2023 Jun;33(6):417-418. doi: 10.1038/s41422-023-00776-5. PMID: 36693900; PMCID: PMC10235072.

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Yu X, Zhao G, Wang D, Wang S, Li R, Li A, Wang H, Nollet M, Chun YY, Zhao T,
Yustos R, Li H, Zhao J, Li J, Cai M, Vyssotski AL, Li Y, Dong H, Franks NP,
Wisden W. A specific circuit in the midbrain detects stress and induces
restorative sleep. Science. 2022 Jul;377(6601):63-72. doi: 10.1126/science.abn0853. Epub 2022 Jun 30. PMID: 35771921; PMCID: PMC7612951.

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Miracca G, Anuncibay-Soto B, Tossell K, Yustos R, Vyssotski AL, Franks NP,
Wisden W. NMDA Receptors in the Lateral Preoptic Hypothalamus Are Essential for
Sustaining NREM and REM Sleep. J Neurosci. 2022 Jul 6;42(27):5389-5409. doi:
10.1523/JNEUROSCI.0350-21.2022. Epub 2022 Jun 1. PMID: 35649726; PMCID:
PMC7613025.

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Yu X, Franks NP, Wisden W. Brain Clocks, Sleep, and Mood. Adv Exp Med Biol. 2021;1344:71-86. doi: 10.1007/978-3-030-81147-1_5. PMID: 34773227.

 

Harding EC, Ba W, Zahir R, Yu X, Yustos R, Hsieh B, Lignos L, Vyssotski AL, Merkle FT, Constandinou TG, Franks NP, Wisden W. Nitric Oxide Synthase Neurons in the Preoptic Hypothalamus Are NREM and REM Sleep-Active and Lower Body Temperature. Front Neurosci. 2021 Oct 14;15:709825. doi: 10.3389/fnins.2021.709825. PMID: 34720852; PMCID: PMC8551479.

 

Franks NP, Wisden W. The inescapable drive to sleep: Overlapping mechanisms of sleep and sedation. Science. 2021 Oct 29;374(6567):556-559. doi: 10.1126/science.abi8372. Epub 2021 Oct 28. PMID: 34709918.

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Harding EC, Franks NP, Wisden W. Sleep and thermoregulation. Curr Opin Physiol. 2020 Jun;15:7-13. doi: 10.1016/j.cophys.2019.11.008. PMID: 32617439; PMCID: PMC7323637.

 

Yu X, Ba W, Zhao G, Ma Y, Harding EC, Yin L, Wang D, Li H, Zhang P, Shi Y, Yustos R, Vyssotski AL, Dong H, Franks NP, Wisden W. Dysfunction of ventral tegmental area GABA neurons causes mania-like behavior. Mol Psychiatry. 2020 Jun 17. doi: 10.1038/s41380-020-0810-9. Epub ahead of print. PMID: 32555422.

 

Nollet M, Wisden W, Franks NP. Sleep deprivation and stress: a reciprocal relationship. Interface Focus. 2020 Jun 6;10(3):20190092. doi: 10.1098/rsfs.2019.0092. Epub 2020 Apr 17. PMID: 32382403; PMCID: PMC7202382.

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Wisden W, Franks NP. The stillness of sleep.  

Science. 2020 Jan 24;367(6476):366-367. doi: 10.1126/science.aba4485. PubMed PMID: 31974235.  

 

Ma Y, Miracca G, Yu X, Harding EC, Miao A, Yustos R, Vyssotski AL, Franks NP, Wisden W. Galanin Neurons Unite Sleep Homeostasis and α2-Adrenergic Sedation.

Curr Biol. 2019 Oct 7;29(19):3315-3322.e3. doi: 10.1016/j.cub.2019.07.087. Epub 2019 Sep 19. PubMed PMID: 31543455; PubMed Central PMCID: PMC6868514.  

 

Yu X, Ma Y, Harding EC, Yustos R, Vyssotski AL, Franks NP, Wisden W. Corrigendum: Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness.

Sleep. 2019 Aug 1;42(8). pii: zsz107. doi: 10.1093/sleep/zsz107. PubMed PMID: 31152538; PubMed Central PMCID: PMC6685315.  

 

Harding EC, Franks NP, Wisden W. The Temperature Dependence of Sleep.

Front Neurosci. 2019 Apr 24;13:336. doi: 10.3389/fnins.2019.00336. eCollection 2019. Review. PubMed PMID: 31105512; PubMed Central PMCID: PMC6491889.  

 

Yu X, Ma Y, Harding EC, Yustos R, Vyssotski AL, Franks NP, Wisden W. Genetic lesioning of histamine neurons increases sleep-wake fragmentation and reveals their contribution to modafinil-induced wakefulness.

Sleep. 2019 May 1;42(5). pii: zsz031. doi: 10.1093/sleep/zsz031. Erratum in: Sleep. 2019 Aug 1;42(8):. PubMed PMID: 30722053; PubMed Central PMCID: PMC6519916.  

 

Yu X, Li W, Ma Y, Tossell K, Harris JJ, Harding EC, Ba W, Miracca G, Wang D, Li L, Guo J, Chen M, Li Y, Yustos R, Vyssotski AL, Burdakov D, Yang Q, Dong H, Franks NP, Wisden W. GABA and glutamate neurons in the VTA regulate sleep and wakefulness.

Nat Neurosci. 2019 Jan;22(1):106-119. doi: 10.1038/s41593-018-0288-9. Epub 2018 Dec 17. PubMed PMID: 30559475; PubMed Central PMCID: PMC6390936.  

 

Paul EJ, Kalk E, Tossell K, Irvine EE, Franks NP, Wisden W, Withers DJ, Leiper J, Ungless MA. nNOS-Expressing Neurons in the Ventral Tegmental Area and Substantia Nigra Pars Compacta.

eNeuro. 2018 Nov 16;5(5). pii: ENEURO.0381-18.2018. doi: 10.1523/ENEURO.0381-18.2018. eCollection 2018 Sep-Oct.  PubMed PMID: 30456293; PubMed Central PMCID: PMC6240015.  

 

Scammell TE, Jackson AC, Franks NP, Wisden W, Dauvilliers Y. Histamine: neural circuits and new medications.

Sleep. 2019 Jan 1;42(1). doi: 10.1093/sleep/zsy183. Review. PubMed PMID: 30239935; PubMed Central PMCID: PMC6335869.  

 

Harding EC, Yu X, Miao A, Andrews N, Ma Y, Ye Z, Lignos L, Miracca G, Ba W, Yustos R, Vyssotski AL, Wisden W, Franks NP. A Neuronal Hub Binding Sleep Initiation and Body Cooling in Response to a Warm External Stimulus.

Curr Biol. 2018 Jul 23;28(14):2263-2273.e4. doi: 10.1016/j.cub.2018.05.054. Epub 2018 Jul 12. PubMed PMID: 30017485; PubMed Central PMCID: PMC6078908.  

 

Yu X, Franks NP, Wisden W. Sleep and Sedative States Induced by Targeting the Histamine and Noradrenergic Systems.

Front Neural Circuits. 2018 Jan 26;12:4. doi: 10.3389/fncir.2018.00004. eCollection 2018. Review. PubMed PMID: 29434539; PubMed Central PMCID: PMC5790777.  

 

Gelegen C, Miracca G, Ran MZ, Harding EC, Ye Z, Yu X, Tossell K, Houston CM,  Yustos R, Hawkins ED, Vyssotski AL, Dong HL, Wisden W, Franks NP. Excitatory Pathways from the Lateral Habenula Enable Propofol-Induced Sedation.

Curr Biol. 2018 Feb 19;28(4):580-587.e5. doi: 10.1016/j.cub.2017.12.050. Epub 2018 Feb 1. PubMed PMID: 29398217; PubMed Central PMCID: PMC5835141.  

 

Wisden W, Yu X, Franks NP. GABA Receptors and the Pharmacology of Sleep.

Handb Exp Pharmacol. 2019;253:279-304. doi: 10.1007/164_2017_56. PubMed PMID: 28993837.  

 

Ye Z, Yu X, Houston CM, Aboukhalil Z, Franks NP, Wisden W, Brickley SG. Fast  and Slow Inhibition in the Visual Thalamus Is Influenced by Allocating GABA(A) Receptors with Different γ Subunits.

Front Cell Neurosci. 2017 Apr 4;11:95. doi:  10.3389/fncel.2017.00095. eCollection 2017. PubMed PMID: 28420966; PubMed Central PMCID: PMC5378722.  

 

Uygun DS, Ye Z, Zecharia AY, Harding EC, Yu X, Yustos R, Vyssotski AL, Brickley SG, Franks NP, Wisden W. Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons.

J Neurosci. 2016 Nov 2;36(44):11171-11184. PubMed PMID: 27807161; PubMed Central PMCID: PMC5148237.  

 

Yu X, Ye Z, Houston CM, Zecharia AY, Ma Y, Zhang Z, Uygun DS, Parker S, Vyssotski AL, Yustos R, Franks NP, Brickley SG, Wisden W. Wakefulness Is Governed by GABA and Histamine Cotransmission.

Neuron. 2015 Jul 1;87(1):164-78. doi: 10.1016/j.neuron.2015.06.003. Epub 2015 Jun 18. PubMed PMID: 26094607; PubMed Central PMCID: PMC4509551.  

 

Zhang Z, Ferretti V, Güntan İ, Moro A, Steinberg EA, Ye Z, Zecharia AY, Yu X, Vyssotski AL, Brickley SG, Yustos R, Pillidge ZE, Harding EC, Wisden W, Franks NP. Neuronal ensembles sufficient for recovery sleep and the sedative actions of  α2 adrenergic agonists.

Nat Neurosci. 2015 Apr;18(4):553-561. doi: 10.1038/nn.3957. Epub 2015 Feb 23. PubMed PMID: 25706476; PubMed Central PMCID: PMC4836567.  

 

Steinberg EA, Wafford KA, Brickley SG, Franks NP, Wisden W. The role of K₂p channels in anaesthesia and sleep.

Pflugers Arch. 2015 May;467(5):907-16. doi: 10.1007/s00424-014-1654-4. Epub 2014 Dec 9. Review. PubMed PMID: 25482669; PubMed Central PMCID: PMC4428837.  

 

Yu X, Zecharia A, Zhang Z, Yang Q, Yustos R, Jager P, Vyssotski AL, Maywood ES, Chesham JE, Ma Y, Brickley SG, Hastings MH, Franks NP, Wisden W. Circadian factor BMAL1 in histaminergic neurons regulates sleep architecture.

Curr Biol. 2014 Dec 1;24(23):2838-44. doi: 10.1016/j.cub.2014.10.019. Epub 2014 Nov 13. PubMed PMID: 25454592; PubMed Central PMCID: PMC4252164.  

 

Baker R, Gent TC, Yang Q, Parker S, Vyssotski AL, Wisden W, Brickley SG, Franks NP. Altered activity in the central medial thalamus precedes changes in the neocortex during transitions into both sleep and propofol anesthesia.

J Neurosci. 2014 Oct 1;34(40):13326-35. doi: 10.1523/JNEUROSCI.1519-14.2014. PubMed PMID: 25274812; PubMed Central PMCID: PMC4180471.  

 

Gelegen C, Gent TC, Ferretti V, Zhang Z, Yustos R, Lan F, Yang Q, Overington  DW, Vyssotski AL, van Lith HA, Wisden W, Franks NP. Staying awake--a genetic region that hinders α2 adrenergic receptor agonist-induced sleep.

Eur J Neurosci. 2014 Jul;40(1):2311-9. doi: 10.1111/ejn.12570. Epub 2014 Mar 27. PubMed PMID: 24674448; PubMed Central PMCID: PMC4215598.  

 

Zecharia AY, Yu X, Götz T, Ye Z, Carr DR, Wulff P, Bettler B, Vyssotski AL, Brickley SG, Franks NP, Wisden W. GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness.

J Neurosci. 2012 Sep 19;32(38):13062-75. PubMed PMID: 22993424; PubMed Central PMCID: PMC3466043.  

 

Pang DS, Robledo CJ, Carr DR, Gent TC, Vyssotski AL, Caley A, Zecharia AY, Wisden W, Brickley SG, Franks NP. An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action.

Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17546-51. doi: 10.1073/pnas.0907228106. Epub 2009 Sep 24. PubMed PMID: 19805135; PubMed Central  PMCID: PMC2751655.